PREWARM: Pre-transplant Renal Ex vivo Warm Assessment through Recirculating Machine perfusion

PREWARM is a prospective clinical transplantation study aiming to create prediction models for post-transplant outcome, which are based on conventional variables and novel multi-omics markers. Deceased donor kidneys will be perfused ex vivo before transplantation and tissue and perfusate samples are obtained. Recipients of these organs will be followed up for 1 year and outcome data are collected. A supervised artificial intelligence approach will then be utilized to combine conventional and multi-omics variables and create prediction models for post-transplant outcome. Typical ex vivo molecular pathways identified in PREPAIR-2 will be used to supervise artificial intelligence algorithms in the PREWARM study.