PREPAIR-2: Physiology of Renal Ex vivo Perfusion for organ Assessment and Injury Repair – 2

In PREPAIR-2, discarded human kidneys will be perfused ex vivo and exposed to the same sample and MRI protocol as in PREPAIR-1, followed by multi-omics and radiomics analyses. Aim of these experiments is to validate pathways and patterns found in ideal porcine kidneys for sub-optimal human donor kidneys. Thus, an array of common molecular and radiological biomarkers that characterize ex vivo perfusion will be identified for kidneys that are close to those that are actually transplanted in humans.